Kink-turn Worked Example

Stage 1 retrieves candidates by tandem non-Watson-Crick topology; Stage 2 applies the motif-specific sheared G.A geometry criteria. Graph matches are candidates, not confirmed kink-turns.

290,864 Search pool
70,701 Stage 1 graph-topology candidates
11,240 Candidates with G·A pairs
4 Representatives shown (of many candidates)
Kink-turn two-stage workflow funnel

Geometry-confirmed Representatives

PDB Context Sheared G.A pairs Loop nucleotides Structure
2GIS SAM-I riboswitch kink-turn (anchor; Montange & Batey 2006) A18-A37, A19-A36, A20-A35 A17,A38,A18,A19,A20,A21,A31,A32,A33,A34,A35,A36,A37 PDB
1E7K U4 snRNA kink-turn bound to 15.5K protein (Vidovic et al. 2000) D32-D44, D33-D43 D34,D42,D28,D29,D30,D31,D32,D33,D43,D44,D45 PDB
4BW0 HMKt-7 kink-turn bound by L7Ae protein (Huang & Lilley 2013) A4-A22, A5-A21, A6-A20 A3,A23,A16,A17,A18,A19,A20,A21,A22,A4,A5,A6,A7 PDB
2OZB U4 snRNA kink-turn within the human Prp31-15.5K-U4 snRNA complex (Liu et al. 2007) F32-F44, F33-F43 F34,F42,F28,F29,F30,F31,F32,F33,F43,F44,F45 PDB

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